abstract：OBJECTIVE:Treatment of restless legs syndrome (RLS) is primarily based on drugs. Since many patients report improvement of symptoms due to cooling their legs, we examined the efficacy of cryotherapy in RLS. PATIENTS AND METHODS:35 patients (28 women, 60.9±12.5years) with idiopathic RLS and symptoms starting not later ...

journal_title：Journal of the neurological sciences

authors： Happe S,Evers S,Thiedemann C,Bunten S,Siegert R

更新日期：2016-11-15 00:00:00

abstract：:Wernicke's encephalopathy is often undiagnosed, particularly in non-alcoholics. There are very few reports of non-alcoholic patients diagnosed with Korsakoff syndrome in the absence of a prior diagnosis of Wernicke's encephalopathy and no studies of diffusion tensor imaging in non-alcoholic Korsakoff syndrome. We repo...

journal_title：Journal of the neurological sciences

authors： Nikolakaros G,Ilonen T,Kurki T,Paju J,Papageorgiou SG,Vataja R

更新日期：2016-11-15 00:00:00

abstract：OBJECTIVE:The present study aims to elucidate the role of Rho-mediated ROCK-Semaphorin3A signaling pathway in the pathogenesis of Parkinson's disease (PD) in a mouse model. METHODS:One-hundred twelve eight-week male C57BL/6 mice were selected. The mouse model of PD was constructed by intraperitoneal injection of MPTP....

journal_title：Journal of the neurological sciences

authors： Qi L,Tang YG,Wang L,He W,Pan HH,Nie RR,Can Y

更新日期：2016-11-15 00:00:00

abstract：:Prolonged-release (PR) fampridine is approved to treat walking impairment in persons with multiple sclerosis (MS); however, treatment benefits may extend beyond walking. MOBILE was a phase 2, 24-week, double-blind, placebo-controlled exploratory study to assess the impact of 10mg PR-fampridine twice daily versus place...

journal_title：Journal of the neurological sciences

authors： Gasperini C,Hupperts R,Lycke J,Short C,McNeill M,Zhong J,Mehta LR

更新日期：2016-11-15 00:00:00

abstract：OBJECTIVE:The aim of the present systematic review is to critically evaluate the effectiveness of OMT as an adjuvant therapy in the management of patients with neurological diseases. METHODS:A systematic review was conducted and the findings were reported following the PRISMA statement. Twelve databases were searched ...

journal_title：Journal of the neurological sciences

authors： Cerritelli F,Ruffini N,Lacorte E,Vanacore N

更新日期：2016-10-15 00:00:00

abstract：BACKGROUND:Motor impairment in Parkinson's disease (PD) includes slowness (bradykinesia), decreased amplitude (hypokinesia), impaired rhythm and a progressive reduction in speed and amplitude during movement repetition (sequence effect). In the present study we aimed to analyse bradykinesia features in newly-diagnosed ...

journal_title：Journal of the neurological sciences

authors： Bologna M,Leodori G,Stirpe P,Paparella G,Colella D,Belvisi D,Fasano A,Fabbrini G,Berardelli A

更新日期：2016-10-15 00:00:00

abstract：OBJECTIVES:Ultra high field MRI at 7T is able to provide much improved spatial and contrast resolution which may aid in the diagnosis of hippocampal abnormalities. This paper presents a preliminary experience on qualitative evaluation of 7T MRI in temporal lobe epilepsy patients with a focus on comparison to histopatho...

journal_title：Journal of the neurological sciences

authors： Kwan BYM,Salehi F,Ohorodnyk P,Lee DH,Burneo JG,Mirsattari SM,Steven D,Hammond R,Peters TM,Khan AR

更新日期：2016-10-15 00:00:00

abstract：:Growth differentiation factor 11 (GDF11), as a rejuvenation factor in heterochronic parabiosis, can increase proliferation of primary brain capillary endothelial cells (ECs). However, the angiogenic role of GDF11 in ischemia-induced brain injury is still unclear. There are no previous reports on the spatiotemporal exp...

journal_title：Journal of the neurological sciences

authors： Ma J,Zhang L,He G,Tan X,Jin X,Li C

更新日期：2016-10-15 00:00:00

abstract：:There are many tools for differentiating between multiple system atrophy with predominant parkinsonian features (MSA-P) and Parkinson's disease (PD). These include middle cerebellar peduncle (MCP) width, apparent diffusion coefficient (ADC) value of the putamen and cerebellum, and (123)I-metaiodobenzylguanidine (MIBG)...

journal_title：Journal of the neurological sciences

authors： Sako W,Abe T,Murakami N,Miyazaki Y,Izumi Y,Harada M,Kaji R

更新日期：2016-09-15 00:00:00

abstract：:Post-stroke epilepsy (PSE) is defined as "recurrent seizures following stroke with confirmed diagnosis of epilepsy". Our objective was to describe the epidemiological, clinical and therapeutic PSE aspects at the Yalgado Ouedraogo Teaching Hospital, the main reference centre for neurological conditions in Burkina Faso....

journal_title：Journal of the neurological sciences

authors： Napon C,Dabilgou A,Kyelem J,Kaboré J

更新日期：2016-09-15 00:00:00

abstract：PURPOSE:Intracranial bleeding and inflammatory reactions are common consequences of traumatic brain injury (TBI). Neutrophil gelatinase-associated lipocalin (NGAL), an iron-handling and acute phase protein, may participate in the pathogenesis of TBI. Therefore, we hypothesize that NGAL may be of high diagnostic and the...

journal_title：Journal of the neurological sciences

authors： Zhao J,Chen H,Zhang M,Zhang Y,Qian C,Liu Y,He S,Zou Y,Liu H

更新日期：2016-09-15 00:00:00

abstract：:Bradykinesia is a disabling symptom of Parkinson's disease (PD) which presents with slowness of movement. Visual assessment using clinical rating scales is currently the gold standard to assess bradykinesia. Such assessments require multiple separate movements, are subjective, and rely on the ability of the rater to d...

journal_title：Journal of the neurological sciences

authors： Delrobaei M,Tran S,Gilmore G,McIsaac K,Jog M

更新日期：2016-09-15 00:00:00

abstract：:Our objective was to apply the technique of measuring diameters of optic nerve sheath (ONSD) for the intracranial pressure assessment for the cases with traumatic head injury without hemorrhage. In a retrospective study, CT data of 720 adult patients were collected and analyzed. ONSDs were measured at the point where ...

journal_title：Journal of the neurological sciences

authors： Bekerman I,Sigal T,Kimiagar I,Vaiman M

更新日期：2016-09-15 00:00:00

abstract：BACKGROUND:The pathogenesis of PD remains elusive. The renin-angiotensin-system (RAS) has recently been implicated in the degeneration of dopaminergic neurons. This study aimed to compare plasma levels of components of the RAS of individuals with PD with controls. We also investigated the association between these circ...

journal_title：Journal of the neurological sciences

authors： Rocha NP,Scalzo PL,Barbosa IG,de Campos-Carli SM,Tavares LD,de Souza MS,Christo PP,Reis HJ,Simões E Silva AC,Teixeira AL

更新日期：2016-09-15 00:00:00

abstract：:Transient global amnesia is a well-described clinical syndrome; however, the pathophysiology is perplexing. Structural imaging indicates that punctuate hippocampal lesions are the representative pathophysiology, although functional neuroimaging studies have reported that the various regions comprising the episodic mem...

journal_title：Journal of the neurological sciences

authors： Moon Y,Oh J,Kwon KJ,Han SH

更新日期：2016-09-15 00:00:00

abstract：:A multitude of factors must be overcome following spinal cord injury (SCI) in order to achieve clinical improvement in patients. It is thought that by combining promising therapies these diverse factors could be combatted with the aim of producing an overall improvement in function. Chondroitin sulphate proteoglycans ...

journal_title：Journal of the neurological sciences

authors： Carwardine D,Wong LF,Fawcett JW,Muir EM,Granger N

更新日期：2016-08-15 00:00:00

abstract：BACKGROUND:Parkinson's Disease (PD) patients are usually divided into Tremor Dominant (TD) and Postural Instability/Gait Difficulty (PIGD) subtypes. The latter is characterized by axial motor symptoms and worse outcomes, possibly also because of comorbid white matter disease. Therefore, the current study investigated t...

journal_title：Journal of the neurological sciences

authors： Moccia M,Tedeschi E,Ugga L,Erro R,Picillo M,Caranci F,Barone P,Brunetti A

更新日期：2016-08-15 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) with a complex etiology. Given the Vitamin D receptor (VDR) gene, it is considered an outstanding risk component associated with MS. The aim of the present study has been to explore and e...

journal_title：Journal of the neurological sciences

authors： Abdollahzadeh R,Fard MS,Rahmani F,Moloudi K,Kalani BS,Azarnezhad A

更新日期：2016-08-15 00:00:00

abstract：BACKGROUND:Platelet-leukocyte aggregations (PLA) play key roles in acute ischemic stroke (AIS) process and they are formed by the combination of P-selectin (SELP) expressed on the surface of the platelet membranes with P-selectin glycoprotein ligand-1(PSGL-1) expressed on the surface of the leukocytes. There are geneti...

journal_title：Journal of the neurological sciences

authors： Tao L,Changfu W,Linyun L,Bing M,Xiaohui H

更新日期：2016-08-15 00:00:00

abstract：:The understanding of the genetic basis of neurological disorders has grown rapidly in the last two decades. Despite the genomic heterogeneity within African populations, large-scale candidate gene or linkage and exome studies are lacking. However, current knowledge on neurogenetics in African populations is limited an...

journal_title：Journal of the neurological sciences

authors： Akinyemi RO,Owolabi MO,Oyeniyi T,Ovbiagele B,Arnett DK,Tiwari HK,Walker R,Ogunniyi A,Kalaria RN,SIREN group of H3Africa Consortium.

更新日期：2016-07-15 00:00:00

abstract：INTRODUCTION:Mirror movements (MM) have been previously reported in patients with Parkinson's disease (PD). Despite being potentially relevant in PD, MM as a neurological sign have remained less recognized. In this study we critically evaluated the characteristic features of MM and their attributes among a cohort of PD...

journal_title：Journal of the neurological sciences

authors： Chatterjee P,Banerjee R,Choudhury S,Mondal B,Kulsum MU,Chatterjee K,Kumar H

更新日期：2016-07-15 00:00:00

abstract：:Since Alzheimer's disease (AD) is becoming the prevalent dementia in the whole world, more underlying mechanisms are emerging. Long time has the transcription factor NF-κB been identified to participate in AD pathogenesis, various studies have focused on the causes and effects of AD that are linked to NF-κB. In this r...

journal_title：Journal of the neurological sciences

authors： Shi ZM,Han YW,Han XH,Zhang K,Chang YN,Hu ZM,Qi HX,Ting C,Zhen Z,Hong W

更新日期：2016-07-15 00:00:00

abstract：:The choice of dopaminergic therapy in early Parkinson disease (PD) is an important clinical decision, yet factors influencing this decision have not been extensively studied. We sought to investigate the factors that may be associated with the choice of dopaminergic therapy at the NINDS Exploratory Trials in PD (NET-P...

journal_title：Journal of the neurological sciences

authors： Goudreau JL,Pérez A,Aminoff MJ,Boyd JT,Burau KD,Christine CW,Leehey M,Morgan JC,NET-PD Investigators.

更新日期：2016-07-15 00:00:00

abstract：:Adenylate kinase 5 (AK5) is one member of the AK family and plays a critical role in maintaining cellular homeostasis. Different from the other AKs, AK5 is almost exclusively expressed in the brain. However, its exact biological functions remain unclear. The aim of the present study is to explore the expression patter...

journal_title：Journal of the neurological sciences

authors： Lai Y,Hu X,Chen G,Wang X,Zhu B

更新日期：2016-07-15 00:00:00

abstract：:Guillain-Barré syndrome (GBS) is considered a monophasic disorder yet recurrences occur in up to 6% of patients. We retrospectively studied an Italian-Japanese population of 236 GBS and 73 Miller Fisher syndrome (MFS) patients and searched for factors which may be associated with recurrence. A recurrent patient was de...

journal_title：Journal of the neurological sciences

authors： Notturno F,Kokubun N,Sekiguki Y,Nagashima T,De Lauretis A,Yuki N,Kuwabara S,Uncini A

更新日期：2016-06-15 00:00:00

abstract：PURPOSE:To introduce the combination of suction thrombectomy (ST) and balloon maceration (BM) for the management of dural venous sinus thrombosis (DVST). MATERIALS AND METHODS:Ten consecutive patients (average age, 53±15years; range, 30 to 73years) with DVST treated by ST after BM were evaluated including location of ...

journal_title：Journal of the neurological sciences

authors： Lee CW,Liu HM,Chen YF,Lin YH,Wang JL

更新日期：2016-06-15 00:00:00

abstract：:Association of changes in olfactory-related structures with olfactory function in patients with multiple sclerosis (MS) is not well understood. We used a T&T olfactometer test kit to evaluate olfactory function in 26 patients with MS and 26 age- and sex-matched healthy controls (HC). Then, Brain MRI were performed and...

journal_title：Journal of the neurological sciences

authors： Li LM,Yang LN,Zhang LJ,Fu Y,Li T,Qi Y,Wang J,Zhang DQ,Zhang N,Liu J,Yang L

更新日期：2016-06-15 00:00:00

abstract：BACKGROUND:Tourette syndrome (TS) is a neurodevelopmental condition characterised by multiple tics and co-morbid behavioural problems. Previous research found that up to 76% of patients with TS experience affective symptoms, with 13% fulfilling diagnostic criteria for depression. OBJECTIVES:We aimed to assess the seve...

journal_title：Journal of the neurological sciences

authors： Piedad JC,Cavanna AE

更新日期：2016-05-15 00:00:00

abstract：PURPOSE:To provide an up-to-date estimate on the changing prevalence of stroke survivors, and examines the geographic and socioeconomic variations in low and middle-income countries (LMICs). METHODS:We searched MEDLINE, EMBASE, SCOPUS and Web of Science databases and systematically reviewed articles reporting stroke p...

journal_title：Journal of the neurological sciences

authors： Ezejimofor MC,Chen YF,Kandala NB,Ezejimofor BC,Ezeabasili AC,Stranges S,Uthman OA

更新日期：2016-05-15 00:00:00

abstract：BACKGROUND AND AIM:Cerebral hemiatrophy (CHA) is a congenital or acquired loss of volume in one hemisphere of the brain. The MR findings of the affected hemisphere have been a subject of many studies, however, the contralateral hemisphere has not been investigated. There is, in fact, an integrity between two hemisphere...

journal_title：Journal of the neurological sciences

authors： Öztoprak B,Öztoprak İ,Bozkurt H,Çiğdem B,Yıldız ÖK

更新日期：2016-04-15 00:00:00

abstract：BACKGROUNDS:Although prevention of hematoma enlargement and thromboembolic complications is critically important in acute intracerebral hemorrhage (ICH) patients with prosthetic heart valves, clinical data are scarce. The goal of this study was to elucidate patient characteristics, acute treatments, and the clinical co...

journal_title：Journal of the neurological sciences

authors： Nishimura K,Koga M,Minematsu K,Takahashi JC,Nagatsuka K,Kobayashi J,Toyoda K

更新日期：2016-04-15 00:00:00

abstract：BACKGROUND:Cerebrovascular reactivity (CVR) is defined as the change in cerebral blood flow, or blood velocity, in response to a vasoactive stimulus. There is a possible association between impaired CVR and vasospasm after aneurysmal subarachnoid hemorrhage. Most studies on CVR and vasospasm have used healthy subjects ...

journal_title：Journal of the neurological sciences

authors： Bøthun ML,Haaland ØA,Logallo N,Svendsen F,Thomassen L,Helland CA

更新日期：2016-04-15 00:00:00

abstract：BACKGROUND:Botulinum toxin A (BTA) responders have elevated levels of calcitonin gene-related and vasoactive intestinal peptides, which are potent vasodilators. We aimed to investigate neurovascular features as a predictor of BTA treatment response in patients with chronic migraine. METHODS:We prospectively recruited ...

journal_title：Journal of the neurological sciences

authors： Lee MJ,Lee C,Choi H,Chung CS

更新日期：2016-04-15 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) is a noninvasive technique to modulate the neural membrane potential. Its effects in the early stage of traumatic brain injury (TBI) have rarely been investigated. This study assessed the effects of anodal tDCS on behavioral and spatial memory in a rat model of traumatic ...

journal_title：Journal of the neurological sciences

authors： Yoon KJ,Lee YT,Chae SW,Park CR,Kim DY

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:Previous studies to estimate burden of neurological disorders in Africa are limited to inpatients in urban hospitals. The spectrum of neurological conditions in rural Africa remains unclear. OBJECTIVE:To determine the spectrum of neurological presentations in an outpatient setting in rural Zimbabwe. METHOD...

journal_title：Journal of the neurological sciences

authors： Vyas MV,Wong A,Yang JM,Thistle P,Lee L

更新日期：2016-03-15 00:00:00

abstract：OBJECTIVE:To determine the influence of different factors on test-retest reliability of frequently used transcranial magnetic stimulation (TMS) parameters while controlling for potential confounders in healthy subjects. METHODS:TMS was applied in 93 healthy volunteers (61% male) twice (mean retest interval of 34.0 ± 2...

journal_title：Journal of the neurological sciences

authors： Hermsen AM,Haag A,Duddek C,Balkenhol K,Bugiel H,Bauer S,Mylius V,Menzler K,Rosenow F

更新日期：2016-03-15 00:00:00

abstract：OBJECTIVE:Cerebral gas embolism (CGE) is a potentially catastrophic complication of central venous catheters (CVCs) manipulation or accidental disconnection, which is rarely reported in the literature. This systematic review aims to characterize the clinical manifestations, imaging features and outcome of CGE associate...

journal_title：Journal of the neurological sciences

authors： Pinho J,Amorim JM,Araújo JM,Vilaça H,Ribeiro M,Pereira J,Ferreira C

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:In Alzheimer's disease, higher educational attainment is associated with fewer cognitive deficits despite similar pathological lesions. In animal models of Parkinson's disease (PD), enhanced levels of cognitive and physical stimulation can reduce motor deficits due to dopaminergic neuronal loss. Therefore, i...

journal_title：Journal of the neurological sciences

authors： Sunwoo MK,Hong JY,Lee JJ,Lee PH,Sohn YH

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:In clinical trials drop out bias reduces the validity of results. This is a particular problem in long-term multiple sclerosis (MS) studies, particularly when patients become progressively disabled and have increasing difficulty attending assessment clinics. OBJECTIVE:To assess the validity of nurse led tel...

journal_title：Journal of the neurological sciences

authors： Huda S,Cavey A,Izat A,Mattison P,Boggild M,Palace J

更新日期：2016-03-15 00:00:00

abstract：:We aimed to clarify the longitudinal course of mild parkinsonian signs (MPS) and their association with dementia and functional disability by conducting a comprehensive epidemiological study, including brain MRI, and assessments of cognition, depression, and sleep, in people aged ≥65years living in Ama-cho. We diagnos...

journal_title：Journal of the neurological sciences

authors： Wada-Isoe K,Tanaka K,Uemura Y,Nakashita S,Tajiri Y,Tagashira S,Yamamoto M,Yamawaki M,Kishi M,Nakashima K

更新日期：2016-03-15 00:00:00